IMMUNOLOCICAL ABNORMALITIES IN CHILDHOOD CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA (ITP)
نویسندگان
چکیده
منابع مشابه
Childhood Idiopathic Thrombocytopenic Purpura (itp): over 40 Year Experiences
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder. Decreased platelet survival is the main pathogenesis of it, which is related to platelet antibodies (APA). The levels of these antibodies are correlated with relapse and remission which was shown first time by us. Although APA levels decrease in remission but not risappear as studied by us. Among the several approches about IT...
متن کاملIdiopathic thrombocytopenic purpura (ITP) in children.
Idiopathic thrombocytopenic purpura in children remits spontaneously in the majority of cases but most children require treatment. Between 1995 and 2005, 265 children (0-15 years old) have been consecutively observed and treated: 28 children with high doses of methylprednisolone (HDMP) (15 mg/kgx4 days), 63 with HDMP (7.5 mg/kgx4 days), 37 with HD dexamethasone (DXM) pulses, 29 with low doses o...
متن کاملAbout treatment of idiopathic thrombocytopenic purpura (ITP).
Their treatment results with megadose methylprednisolone (MDMP) support fairly closely our complete remission results, though theirs was a retrospective evaluation. In our prospective, comparative study, antiplatelet antibodies were also determined3. Their 80% complete remission rate (mistakenly written as 66% in the text) with MDMP administration was much better than other therapeutic approach...
متن کاملIdiopathic thrombocytopenic purpura in childhood.
Purpura is a relatively common symptom in childhood and may be due to a variety of causes. A platelet count enables one to exclude the nonthrombocytopenic variety, but more elaborate investigations are needed to exclude other primary conditions which are often associated with thrombocytopenia, e.g. leukaemia. There remains a group of patients with idiopathic thrombocytopenic purpura and it is w...
متن کاملUpdate on chronic immune thrombocytopenic purpura (ITP)
Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1977
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197704000-00670